Author/Editor		Jeruc, Jera; Zidar, Nina; Gale, Nina; Coer, Andrej
Title		Apoptosis and proliferation in epithelial hyperplasia and squamous cell carcinoma of the pharynx and oral cavity
Type		članek
Source		In: Gale N, Žargi M, editors. Epithelial tumours of the head and neck. Proceedings of the 31st memorial meeting for professor Janez Plečnik under the auspices of the European society of pathology; 2000 Dec 7-8; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		2000
Volume		str. 153-6
Language		eng
Abstract		Recent studies have demonstrated that balance between cell proliferation and cell loss might play a vital role in carcinogenesis. We therefore analyzed the proliferative activity using anti-Ki-67 antibody and spontaneous apoptosis evaluated by TUNEL method, in 36 oral and pharyngeal biopsies with increasing grades of epithelial hyperplasia (EH) and squamous cell carcinoma (SCC). In EH, scarce TUNEL positive cells were observed in atypical hyperplasia; positive reaction was also found in parakeratotic cells in all cases of EH with parakeratosis. The percentage of Ki-67 positive cell progressively increased with the degree of EH. In SCC, the percentage of Ki-67 positive cell increased, while the percentage of TUNEL positive cells tended to decrease with the grade of SCC. Our preliminary study suggests an inverse relationship between the proliferative activity and apoptosis with increasing grade of SCC and is in accordance with the hypothesis that tumor growth and progression is based on the disarranged balance between cell proliferation and cell loss.
Descriptors		PHARYNGEAL NEOPLASMS MOUTH NEOPLASMS CARCINOMA, SQUAMOUS CELL APOPTOSIS HYPERPLASIA NEOPLASM STAGING KI-67 ANTIGEN