Author/Editor     Brecelj, Jelka; Stirn-Kranjc, Branka; Škrbec, Miha
Title     Visual electrophysiology in children with tumours affecting the visual pathway
Type     članek
Source     Doc Ophthalmol
Vol. and No.     Letnik 101
Publication year     2000
Volume     str. 125-54
Language     eng
Abstract     In 9 children (8-14 years of age) with orbital, suprasellar or postchiasmal tumours, visual loss was studied by visual electrophysiology in relation to ophthalmologic and neuroimaging findings. Pattern electroretinography (PERG) and pattern visual evoked potentials (PVEP) to full and half-field pattern-reversal stimulation were recorded and PERG and PVEP changes were related to the tumour location. PERG wave P50 attenuation was found associated with the central retinal dysfunction in the child with orbital rhabdomyosarcoma; PVEP wave P100 delay was associated with the optic nerve dysfunction in a child with retrobulbar chondrosarcoma and in a child with optic nerve glioma; PVEP wave P100 asymmetry was associated with the crossed fibres dysfunction in a child with hypothalamine germinoma, and PVEP wave P 100 uncrossed asymmetry was associated with postchiasmal dysfunction in children with postchiasmal tumours (one with pilocytic astrocytoma and two with angioma). On the other hand, normal PERG suggested that there was no central retinal dysfunction in a child with pleomorphic adenoma of the lacrimal gland, and normal PVEP to full and half-filed stimulation excluded visual pathway dusfunction at the chiasm in a child with suprasellar arachnoidal cyst. Follow-up was useful in indicating whether visual dysfunction was progressive or not. We conclude that PERG and PVEP findings contributed to understanding whether the dysfunction originated was at the retina, in the optic nerve, chiasm or postchiasmal pathway.
Descriptors     ORBITAL NEOPLASMS
OPTIC NERVE
CRANIAL NERVE NEOPLASMS
ELECTRORETINOGRAPHY
EVOKED POTENTIALS, VISUAL
CHILD
GLIOMA
CHONDROSARCOMA
VISUAL PATHWAYS
RHABDOMYOSARCOMA
HYPOTHALAMIC NEOPLASMS
CENTRAL NERVOUS SYSTEM NEOPLASMS
TOMOGRAPHY, X-RAY COMPUTED
TREATMENT OUTCOME