Author/Editor     Košnik, Mitja; Kern, Izidor; Mušič, E
Title     Chloroquin-induzierte arzneimitteltoxische alveolitis
Translated title     Chloroquine-induced drug-hypersensitivity
Type     članek
Source     Pneumologie
Vol. and No.     Letnik 54
Publication year     2000
Volume     str. 395-7
Language     ger
Abstract     Chloroquine-Induced Drug-Hypersensitivity: This case history presents a 41-years-old man with chronic discoid erythematosus who was treated with chloroquine. After 2 weeks of treatment he developed dyspnea, purulent sputum, high fever, diffuse papular rash, and diffuse peripheral homogeneous infiltrates on chest x-ray. Rapid recovery occurred after discontinning chloroquine. Subsequent peroral provocation with chloroquine caused symptoms suggestive of hypersensitivity pneumonitis. Analysis of bronchoalveolar lavage fluid showed eosinophilia and a reduced CD4/CD8 ratio. Although treatment with chloroquine is often complicated by side effects, in a literature search we could not find any report on acute pneumonitis.
Descriptors     LUPUS ERYTHEMATOSUS, DISCOID
DRUG HYPERSENSITIVITY
CHLOROQUINE
ALVEOLITIS, EXTRINSIC ALLERGIC
ADULT