Author/Editor		Meden-Vrtovec, H; Tomaževič, T; Verdenik, I
Title		Infertility treatment by in vitro fertilization in patients with minimal or mild endometriosis
Type		članek
Source		Clin Exp Obstet Gynecol
Vol. and No.		Letnik 27, št. 3-4
Publication year		2000
Volume		str. 191-3
Language		eng
Abstract		Purpose: To estimate the clinical effectiveness of in vitro fertilization treatment in patients with minimal or mild endometriosis (stage I and II) in comparison to the patients with tubal infertility in terms of fertilization, pregnancy and livebirth rates. Methods: Retrospective analysis of the outcome of IVF-ET in 612 cycles of the patients with endometriosis (389 stimulated with HMG/HCG and 223 co-treated with GnRH-a) and in 7,339 cycles of the patients with tubal infertility (5.520 stimulated with HMG/HCG and 1,819 co-treated with GnRH-a). Results: Regardliness of the type of ovarian stimulation, the fertilization rate per treated cycle was practically the same in both groups (endometriosis 81.4% vs tubal infertility 84,2%; p=0.07). However, in the endometriosis group the pregnancy rate was higher (25.3% vs 18.9%; p=0.000), and so was the livebirth rate (19.0% vs 14.2%; p=0.003). Considering the type of ovarian stimulation, the fertilization rate in the endometriosis group was almost the same in the HMG/HCG (81.2%) and in the GnRH-a co-treated cycles (81.6%), and did not differ from that in the tubal infertility group (83.6% in the HMG/HCG vs 85..9% in the GnRH-a cycles). In the GnRH-a co-treated cycles the pregnancy rate and the livebirth rate were not significantly higher in the endonmetriosis group than in the tubal infertility group (27% and 20.2% vs 22.2% and 17.5%). In the HMG/HCG stimulated cycles the pregnancy rate was significantly higher in the endometriosis than in the tubal infertility group (24.3% vs 17.7%; p=0.004), and so was the liverbirth rate (18.4% vs 13.0%; p=0.008). Conclusion: In patients with minimal or mild endometriosis the IVF-ET procedure is at least as effective as in patients with tubal infertility.
Descriptors		INFERTILITY, FEMALE ENDOMETRIOSIS FERTILIZATION IN VITRO OVULATION INDUCTION EMBRYO TRANSFER PREGNANCY RETROSPECTIVE STUDIES MENOTROPINS GONADOTROPINS, CHORIONIC GONADORELIN TREATMENT OUTCOME