Author/Editor		Serša, Gregor; Čemažar, Maja
Title		Tumor blood flow modifying and anti-vascular effect of electrochemotherapy
Type		članek
Source		In: Jarm T, Kotnik T, Miklavčič D, editors. Proceedings including program of the 3rd international conference on bioelectromagnetism and 1st Slovenian-Croatian meeting on biomedical engineering in connection with COST 244bis 11th workshop on biomedical applications of electromagnetic fields and management commitee meeting; 2000 oct 8-12; Bled. Ljubljana: Faculty of electrical engineering,
Publication year		2000
Volume		str. 11-2
Language		eng
Abstract		The aim of this study was to determine the tumor blood flow modifying, and anti-vascular effect of electrochemotherapy with bleomycin or cisplatin. A complete shut-down of tumor blood flow was observed after electrochemotherapy with bleomycin and 50% reduction after electrochemotherapy with cisplatin. Tumor blood flow reduction following electrochemotherapy correlated well with its antitumor effectiveness. The results of HMEC-1 cells in vitro indicate a high sensitivity of endothelial cells to electrochemotherapy. Electrochemotherapy with bleomycin resulted in a greater potentiation of cytotoxicity compared to electrochemotherapy with cisplatin on HMEC1 cells. Therefore, the results indicate that the antitumor effect of electrochemotherapy is likely to be due partly to increased drug delivery and partly to anti-vascular action.
Descriptors		SARCOMA, EXPERIMENTAL BLEOMYCIN CISPLATIN ELECTROPORATION DRUG DELIVERY SYSTEMS MICE ENDOTHELIUM, VASCULAR BLOOD FLOW VELOCITY