Author/Editor		Kranjc, Simona; Čemažar, Maja; Grošel, Alenka; Serša, Gregor
Title		Electroporation increases radiosensitizing effect of cisplatin on LPB fibrosarcoma
Type		članek
Source		In: Jarm T, Kotnik T, Miklavčič D, editors. Proceedings including program of the 3rd international conference on bioelectromagnetism and 1st Slovenian-Croatian meeting on biomedical engineering in connection with COST 244bis 11th workshop on biomedical applications of electromagnetic fields and management commitee meeting; 2000 oct 8-12; Bled. Ljubljana: Faculty of electrical engineering,
Publication year		2000
Volume		str. 17-8
Language		eng
Abstract		Some chemotherapeutic drugs, like cisplatin, have also radiosensitizing effect. It is presumed, that by increased drug accumulation, radiation response can be potentiated. Application of electric pulses to the cells and tissues was found to be an approach that increases drug delivery into the cells and tissues. This approach, electrochemotherapy, was combined with irradiation of tumor cells in vitro and irradiation of tumors in vivo. In the study on LPB fibrosarcoma we demonstrated increased radiation response of LPB cells in vitro and of tumors in mice. Tumor curability was icreased for 40% when electrochemotherapy was combined with irradiation of tumors compared to irradiation only, and for 30% compared to radiosensitizing effect of cisplatin alone.
Descriptors		FIBROSARCOMA ELECTROPORATION CISPLATIN RADIATION TOLERANCE MICE, INBRED C57BL DRUG DELIVERY SYSTEMS