Author/Editor		Puc, Marko; Kotnik, Tadej; Mir, Lluis M; Miklavčič, Damijan
Title		Pharmacokinetic model of transmembrane transport caused by electropermeabilization
Type		članek
Source		In: Jarm T, Kotnik T, Miklavčič D, editors. Proceedings including program of the 3rd international conference on bioelectromagnetism and 1st Slovenian-Croatian meeting on biomedical engineering in connection with COST 244bis 11th workshop on biomedical applications of electromagnetic fields and management commitee meeting; 2000 oct 8-12; Bled. Ljubljana: Faculty of electrical engineering,
Publication year		2000
Volume		str. 61-2
Language		eng
Abstract		Electropermeabilization of the cell plasma membrane is a well-known phenomenon caused by an exposure to electric pulses. Permeabilization of plasma membrane allows nonpermeant molecules to be introduced into the cells. Transmembrane transport can proceed by diffusion, electrophoresis and osmosis. We have developed a two-compartment pharmacokinetic model that uses diffusion as the transport mechanism. The results showed that this model can predict uptake of small molecules. With the analysis of survival and permeabilization, we demonstrated that their dependence on pulse amplitude can be explained by the distribution of cell size within the population studied.
Descriptors		CELL MEMBRANE PERMEABILITY ELECTROPORATION PHARMACOKINETICS MODELS, CHEMICAL OSMOSIS ELECTROPHORESIS DIFFUSION