Author/Editor		Kamenik, Mirt
Title		Spremembe hemodinamskih parametrov pri subarahnoidni blokadi: primerjava 0,5% bupivakaina in 2% lidokaina
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1996
Volume		str. 50
Language		slo
Abstract		Cardiovascular instability after spinal anesthesia is an undesired side effect necessitating the use of fluid and vasoactive substances to maintain blood pressure. 2% lidocaine and 0.5% plain bupivacaine are often used for subarachnoid blockade. Our study was done in an attempt to clarify the question, whether the decrease in blood pressure and in cardiac output is smaller if 2% lidocaine is used for subarachnoid blockade instead of 0.5% plain bupivacaine, at the same level of sensory blockade. A controlled, double blind, randomized trial was performed on 30 patients scheduled for arthroscopic knee surgery. 15 patients received 2% lidocaine and 15 patients received 0.5% plain bupivacaine for spinal anesthesia. After initiating spinal anesthesia we measured cardiac output (thoracic bioimpedance method), stroke volume, heart rate, blood pressure and sensory blockade development for 25 minutes. For data analysis the patients in each group were further subdivided into two groups according to the highest level of sensory blockade development (above or below Th6 dermatome). Analysis of variance (ANOVA) with repeated measurements for two samples was done separately for high and low level of blockade to compare the hemodynamic effects of both anesthetics. P<0.05 was considered statistically significant. 18 patients developed a sensory blockade below the Th6 dermatome, 10 patients received 2% lidocaine and 8 received 0.5% plain bupivacaine for spinal anesthesia. In this group of patients there was no statistically significant difference between both anesthetics in hemodynamic measurements. (Abstract truncated at 2000 characters)
Descriptors		ANESTHESIA, SPINAL BUPIVACAINE LIDOCAINE HEMODYNAMICS SUBARACHNOID SPACE BLOOD PRESSURE CARDIAC OUTPUT KNEE JOINT ARTHROSCOPY HEART RATE CARDIOGRAPHY, IMPEDANCE NERVE BLOCK DOUBLE-BLIND METHOD RANDOMIZED CONTROLLED TRIALS CARDIOVASCULAR DECONDITIONING