Author/Editor		Petrovič, Daniel; Zorc, M; Keber, I; Peterlin, B
Title		Joint effect of G1691A factor V point mutation and factor VII Arg/Lln353 gene polymorphism on the risk of premature coronary artery disease
Type		članek
Source		Ann Genet
Vol. and No.		Letnik 44
Publication year		2001
Volume		str. 33-6
Language		eng
Abstract		The study, sought an association between the G1691A factor V point mutation and factor VII Arg/Gln353 gene polymorphism and premature coronary artery disease (CAD), and the interactive effect on CAD risk between the G1691A factor V point mutation and factor VlI Arg/Gln353 gene polymorphism as well as between tested polymosphisms and traditional risk factors. 167 patients with CAD younger than 55 years were compared with 132 healthy subjects. The frequency of factor V point mutation was 7.8 % among Slovene patients with premature CAD, and 4.5 % among controls. No association was found between either the factor V point mutation (AG genotype) or M1M1 genotype of factor VII Arg/Gln353 gene polymorphism and the risk of CAD in Slovenia using univariate analysis (factor V point mutation: OR = 1.8, 95% CI = 0.7-4.9; p = 0.25; factor VII Arg/Gln353 gene polymorphism: OR = 1, 95 % CI = 0.6-1.7; p = 0.9). However, a joint effect on the risk of CAD was found between factor V point mutation (AG genotype) and MIM1 genotype (OR =3.6, 95 % CI = 1-12.9; p = 0.03). Additionally, an interactive effect on CAD risk was found between AG genotype and metabolic risk factors (OR = 3.8, 95% CI = 1.1-13.6; p = 0.03). Iu conclusion, we provide evidence for a joint effect on CAD risk between G1691A factor V point mutation and factor VII Arg/Gln353 gene polymorphism as well as between factor V point mutation and metabolic risk factors.
Descriptors		CORONARY DISEASE POINT MUTATION POLYMORPHISM (GENETICS) RISK FACTORS FACTOR VA FACTOR VII GENOTYPE BODY MASS INDEX TRIGLYCERIDES HYPERTENSION DIABETES MELLITUS SMOKING CHOLESTEROL LIPOPROTEINS, LDL CHOLESTEROL LIPOPROTEINS, HDL CHOLESTEROL