Author/Editor		Planinšek, Odon; Pišek, Robert; Kristl, Albin; Schmidt, Peter C; Srčić, Stanko
Title		Increased aqueous solubility of N-(7-oxododecanoyl)-L-alanyl-D-isoglutamine by coprecipitating with various pharmaceutical carriers
Translated title		Povečana topnost N-(7-oksododekanoil)-L-alanil-D-izoglutamina v vodi z izdelavo koprecipitatov z različnimi pomožnimi snovmi
Type		članek
Source		Acta Pharm Zagreb
Vol. and No.		Letnik 49, št. 2
Publication year		1999
Volume		str. 89-98
Language		eng
Abstract		N-(7-oxododecanoyl)-L-alanyl-D-isoglutamine, which is a modified N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP, the smallest immunologically active glucopeptide's subunit of the bacterial cell wall), was chosen after immunorestorement tests for further preclinical testing. For the preparation of an appropriate parenteral formulation, the solubility of the compound has to be increased. For this purpose different physical mixtures and solid dispersions prepared by solvent evaporation method with different carriers were investigated. The solubility of N-(7-oxododecanoyl)-L-alanyl-D-isoglutamine increased from 0.16 g L-1 to 27 g L-1 for the dispersion with nicotinamide, to 40 g L-1 for the dispersion with sodium salicylate and to 24 g L-1 for the complex with 2-hydroxypropyl-beta-cyclodextrin.
Summary		N-(7-oksododekanoil)-L-alanil-D-izoglutamin je bil izbran po testu imunorestavracije na živalih kot ustrezna učinkovina za nadaljna testiranja. Njegova nizka vodotopnost je omejitev pri izdelavi parenteralnega pripravka. V delu smo neravnotežno topnost in hitrost raztapljanja N-(7-oksododekanoil)-L-alanil-D-izoglutamina v vodi povečali s pripravo trdnih disperzij z metodo evaporacije topila. Topnost N-(7-oksododekanoil)-L-alanil-D-izoglutamina po 24 urah smo z 0,16 g L-1 povečali na 27 g L-1 s pripravo trdnih disperzij z nikotinamidom, na 40 g L-1 z natrijevim salicilatom in na 16 g L-1 z 2-hidroksipropil-beta-ciklodekstrinom.
Descriptors		ACETYLMURAMYL-ALANYL-ISOGLUTAMINE SOLUTIONS DRUG CARRIERS SOLUBILITY NIACINAMIDE SODIUM SALICYLATE CYCLODEXTRINS DIFFERENTIAL THERMAL ANALYSIS