Author/Editor		Cvelbar, Mirjam; Kralj, Božo
Title		Zgodnje odkrivanje epitelnega karcinoma jajčnika: analiza podatkov operiranih bolnic na Ginekološki kliniki v Ljubljani v obdobju 1996-1997
Translated title		Early detection of epithelial ovarian cancer: analysis of the data of the patients operated at Department of gynecology and obstetrics in Ljubljana during 1996-1997
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 70, št. 2
Publication year		2001
Volume		str. 81-4
Language		slo
Abstract		Background. In spite of intensive molecular studies and some new insights regarding the beginning and development of epithelial ovarian cancer, world statistics as well as Slovenian one speaks about low grade of early detection and consecutivelly low 5-years survival of the patients. The purpose of our study was to establish retrospectivelly the level of early detection in the group of patients operated at Department of Gynecology and Obstetrics in Ljubljana in the period 1996-1997. Methods and results. One-hundred-twelve patients, operated because of epithelial ovarian cancer in 1996 and 1997, entered the study. One the basis of their clinical documentation we analised stage of their cancer illness at definite surgical-pathohistologic diagnosis, then relationship between stage and age, histologic type, grade and its relation with age. We compared results of early detection during 1996-97 with the results of a former study for the period 1981-90. Chi2 test was used. The difference between the percent of in-the 1st-stage-diagnosed epithelial ovarian cancer in the period 1981-90 (23.3%) and between correspondent percent in the period 1996-97 (38.4%) was statistically significant (p<0.003). Even after performing correction of 1981-90 result, including borderline epithelial tumors, the difference was still significant (p<0.05). We also established connection between younger age (till 40 years), early stage and low grade, and converselly between older age (over 60 years), advanced stage and high grade, even though we did not perform statistical evaluation. Conclusions. Early detection of epithelial ovarian cancer in the period 1996-97 was significantly improved according to former results. Probably the reason is already widespread use of vaginal ultrasound at the primary health care level. (Abstract truncated at 2000 characters.)
Summary		Izhodišča. Kljub intenzivnim molekularnim raziskavam in nekaterim novim spoznanjem o nastanku in napredovanju epitelnega karcinoma jajčnika statistični podatki tako v svetovnem kot v slovenskem merilu govorijo o nizki stopnji zgodnjega odkrivanja te bolezni in o posledičnem nizkem 5-letnem preživetju. Namen naše raziskave je bil retrospektivno ugotoviti, kakšna je bila uspešnost zgodnjega odkrivanja pri bolnicah, ki so bile operirane na Ginekološki kliniki v Ljubljani v letih 1996 in 1997. Metode in rezultati. V raziskavo je bilo vključenih 112 bolnic, operiranih zaradi epitelnega karcinoma jajčnika v letih 1996 in 1997. Pri vseh smo na osnovi klinične dokumentacije analizirali stadij karcinoma ob dokončni kirurško-histološki diagnozi, razmerje med stadijem in starostjo, histološki tip, gradus in njegovo povezavo s starostjo. Rezultati zgodnjega odkrivanja v obdobju 1996-97 smo primerjali z rezultatom predhodne študije za obdobje 1981-90. Pri tem smo uporabili test hi2. Razlika med odstotkom v I. stadiju ugotovljenih karcinomov jajčnika v obdobju 1981-90 (23,3%) in med ustreznim odstotkom v obdobju 1996-97 (38,4%) je bila statistično značilna (p<0,003). Tudi potem, ko smo rezultat za obdobje 1981-90 korigirali z vključitvijo mejno malignih tumorjev, je bila razlika še vedno statistično značilna (p<0,05). Ugotavljali smo tudi povezanost med nižjo starostjo (do 40 let), zgodnjim stadijem in nizkim gradusom ter nasprotno med višjo starostjo (nad 60 let), napredovalim stadijem in visokim gradusom tumorja, ki pa je nismo z multifaktorialno analizo statistično ovrednotili. Zaključki. Zgodnje odkrivanje epitelnega karcinoma jajčnika je bilo v obdobju 1996-97 statistično značilno izboljšano glede na dosedanje rezultate. Vzrok za to je verjetno predvsem široka uporaba vaginalnega ultrazvoka na ravni primarnega zdravstvenega varstva. (Izvleček prekinjen pri 2000 znakih.)
Descriptors		OVARIAN NEOPLASMS NEOPLASM STAGING