Author/Editor		Zver, Samo; Preložnik-Zupan, Irena
Title		Hematološka in nevrološka bolezen kot verjetni posledici okužbe z virusom HIV
Translated title		HIV infection with probably secondary manifestation of hematological and neurological disease
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 70, št. 2
Publication year		2001
Volume		str. 85-7
Language		slo
Abstract		Background. Mostly hematological diseases are idiopathic in origin. Only rarely secondary cause is possible to identify and in such circumstances we are describing hematologic disease as secondary. Beside pretreatment of different cancer diseases with chemotherapy also infection with human immunodeficiency virus (HIV) can be underlaying cause for newly formed hematological disease. But because of fortunattely low number of HIV positive persons in Slovenian population, we rarely connect hematological illness with HIV infection. Patients and methods. We have described young male with leukemic form of Burkitt lymphoma, a subtype of acute lymphoblastic leukemia. Despite well known link between Burkitt lymphoma and HIV infection we have not diagnosed HIV infection until unusual neurological symptoms evoluted. Guillain-Barre syndrome (GBS) was diagnosed, also possible consequence of precedent HIV infection. We have influenced on HIV disease activity with chemotherapy and especially glucocorticosteroids treatment. Conclusions. Brief review of HIV associated hematological and neurological diseases are added.
Summary		Izhodišča. Večinoma opredelimo krvne bolezni kot primarne oziroma idiopatske. Le redko poznamo škodljiv dejavnik in takrat lahko ocenimo novonastalo krvno bolezen kot sekundarno. Poleg zdravljenja različnih rakavih bolezni s kemoterapijo je predhodna okužba z virusom imunske pomanjkljivosti (HIV) najpogostejši vzrok za nastanek sekundarne krvne bolezni. Ker pa je število okuženih z virusom HIV v Sloveniji majhno, na to možnost redko pomislimo. Bolniki in metode. Opisujemo mladega bolnika, ki je zbolel za levkemizirano obliko Burkittovega limfoma oz. akutno limfoblastno levkemijo. Kljub temu da je povezava med Burkittovim limfomom in okužbo z virusom HIV znana, smo vzročno povezavo odkrili šele ob pojavi nenavadne nevrološke simptomatike. Šlo je za Guillain-Barrejev sindrom (GBS), ki je prav tako lahko posledica okužbe z virusom HIV. Na aktivnost okužbe z virusom HIV smo pri bolniku vplivali s citostatskim zdravljenjem krvne bolezni in glukokortikosteroidi. Zaključki. V zaključku je tudi kratek pregled krvnih in nevroloških bolezni, povezanih z virusom HIV.
Descriptors		HIV INFECTIONS HEMATOLOGIC DISEASES NEUROLOGIC MANIFESTATIONS ADULT LYMPHOMA, AIDS-RELATED BURKITT'S LYMPHOMA LEUKEMIA, LYMPHOCYTIC, ACUTE GLUCOCORTICOIDS ACQUIRED IMMUNODEFICIENCY SYNDROME POLYRADICULONEURITIS