Author/Editor     Cerar, A
Title     Vpliv nekaterih virusov na "in vivo" rast malignega tumorja miši
Translated title     The effect of some viruses on the "in vivo" growth of a malignant tumor of mice
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     1990
Volume     str. 80
Language     slo
Abstract     The author studied the "in vivo" influence of Newcastle disease virus on the growth of Ehrlich ascites tumor which was transplanted subcutanously or intraperitoneally. He used a wild and vaccinal strain of Newcastle disease virus and inbred strain of CBA mice. The lenght of survival of animals, the volume of ascites and the solid growth was measured and the tumor growth and metastasation evaluated by histologic and sterologic methods. Flow-cytometric measurements were also applied. The results were statistically evaluated. The inhibitory effect of the virus on the tumor growth was found. The virus significantly prolonged the survival of animals, in some percent it cured the tumor and had principally inhibitory effect on the tumor growth and metastasation. The inhibitory effect was influenced by the strain of the virus, the virus dose and by the system of application and the number of applications. No signs of acute pathogenicity on the CBA mice by the virus was found. With flow-cytometric evaluation the author found that the tumor is composed of two different cell populations, that the virus proliferative activity of tumor cells is stimulated. The tumor inhibitory effect of Newcastle disease virus is not supposed to be induced by the antigenic alteration of the tumor cells but more probably by the direct lytic or toxic effect of the virus on the tumor cells. The informations from the literature support the idea that the inhibitory effect is produced by interferon, which is induced by Newcastle disease virus. Interferon on the other side has many effects on immune mechanisms The effect by tumor necrosis factor is also possible
Descriptors     NEWCASTLE DISEASE VIRUS
CARCINOMA, EHRLICH TUMOR
SURVIVAL ANALYSIS
FLOW CYTOMETRY
MICE
ANIMALS, LABORATORY
NEWCASTLE DISEASE