Author/Editor		Ećimović, Partricija
Title		Pojav drugih primarnih rakov pri bolnikih z rakom grla v Sloveniji v obdobju 1961-1996: primer območne karcinogeneze
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 53
Language		slo
Abstract		Background: The survival of patients with laryngeal cancer in Slovenia is poorer than in most European countries. One of the reasons could be high incidence of second primary cancers (SPC) in this population. Our aim was to ascertain incidence, time and site pattern of occurrence of SPC in patients with laryngeal cancer in Slovenia. Material and Methods: We conducted a retrospective cohort trial, which included 2435 patients with laryngeal cancer, registered at Cancer Registry of Slovenia in the period from 1961 to 1996. We excluded the patients in whom laryngeal cancer was established at autopsy or from death certificate or was a second primary cancer. To determine the SPC, we used criteria recommended by IARC/IACR. We included both synchronous and metachronous SPC. We used the person-years approach and expressed the occurrence of SPC as standardized incidence ratio (SIR). We performed a separate analysis of incidence of SPC by follow-up time and by sub site of primary cancer (glottis and other parts of larynx). Results: The average period of follow-up in our cohort was 4.78 years (range 0 to 27.8 years). SPC developed in 390 patients (16.02%, total SIR=2.83), most commonly in the head and neck region (SIR=9.96 for men and 100.0 for women), lung (SIR=4.14 for men and 20.7 for women) and esophagus (SIR=4.65 for men), which points to the strong role of common risk factors of smoking and alcohol. Males were at higher risk of developing SPC than females. Patients with cancer in other parts of the larynx were at higher risk than patients with glottis cancer. SPC were diagnosed in significant excess up to 20 years after the diagnosis of laryngeal cancer. Patients with glottis cancer had higher risk for SPC of the bladder. Other than that, we found no major difference in time and site distribution of SPC after the patients with glottis cancer and the patients with cancer in other parts of the larynx were analyzed separately. (Abstract truncated at 2000 characters)
Descriptors		LARYNGEAL NEOPLASMS NEOPLASMS, SECOND PRIMARY SLOVENIA COHORT STUDIES REGISTRIES TIME FACTORS RISK FACTORS SURVIVAL RATE SMOKING ALCOHOLISM