Author/Editor     Jordanova, Vesna; Dernovšek, Mojca Z
Title     Novejši stabilizatorji razpoloženja
Translated title     New mood stabilizers
Type     članek
Source     Zdrav Vars
Vol. and No.     Letnik 40, št. 1-2
Publication year     2001
Volume     str. 77-80
Language     slo
Abstract     Bipolar affective disorder is characterized by more or less rapid changing of manic and depressive episodes. This cycling can be slowed down or prevented with some drugs, which are called mood stabilizers. Besides older and well-established drugs like lithium and carbamazepine, some new drugs have recently been introduced. These drugs mostly belong to a group of antiepileptics (sodium valproate, lamotrigine, gabapentine, clonazepam), calcium channel antagonists (verapamil, nimodipine, nifedipine) and atypical antipsychotics (risperidone, olanzapine, clozapine). This paper deals with basics of pharmacodynamics and pharmacokinetics of mentioned newer drugs and gives numerous hints for their use in practice.
Summary     Za bipolarno motnjo razpoloženja so značilne bolj ali manj hitre menjave faz, to je maničnih in depresivnih epizod. Menjavanje faz skušamo upočasniti ali preprečiti z nekaterimi zdravili, ki jih imenujemo stabilizatorji razpoloženja. Poleg že znanih in uveljavljenih stabilizatorjev razpoloženja, kot sta litij in karbamazepin, se predvsem v zadnjem času pojavljajo številna nova zdravila, zlasti iz skupine antiepileptikov (natrijev valproat, lamotrigin, gabapentin, klonazepam), kalcijevih antagonistov (verapamil, nimodipin, nifedipin) in atipičnih antipsihotikov (risperidon, olanzapin, klozapin). Prispevek obravnava osnove farmakodinamike in farmakokinetike navedenih zdravil ter daje nekatere napotke za praktično uporabo.
Descriptors     MENTAL DISORDERS
BIPOLAR DISORDER
ANTICONVULSANTS
CALCIUM CHANNEL BLOCKERS
ANTIPSYCHOTIC AGENTS
VALPROIC ACID