Author/Editor     Čižman, Milan; Pokorn, Marko; Seme, Katja; Oražem, Andreja; Paragi, Metka
Title     The relationship between trends in macrolide use and resistance to macrolides of common respiratory pathogens
Type     članek
Source     J Antimicrob Chemother
Vol. and No.     Letnik 47, št. 4
Publication year     2001
Volume     str. 475-7
Language     eng
Abstract     The correlation between increased macrolide consumption and the resistance of Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to macrolides in Slovenia from 1994 to 1999 was evaluated. The outpatient consumption of macrolides increased from 1.89 to 3.84 defined daily doses (DDD)/1000 inhabitants/day during the observation period. This increase in macrolide consumption was paralleled by a steady increase in macrolide resistance in S. pyogenes (from 0 to 7.4%, r =0.90, P=0.014) and upper respiratory S. pneumoniae isolates (from 0 to 9%, r =0.82, P=0.044). In other pathogens studied, no significant increase was detected.
Descriptors     RESPIRATORY TRACT INFECTIONS
ANTIBIOTICS, MACROLIDE
DRUG RESISTANCE, MICROBIAL
STREPTOCOCCUS PNEUMONIAE
STREPTOCOCCUS PYOGENES
HAEMOPHILUS INFLUENZAE
MORAXELLA (BRANHAMELLA) CATARRHALIS
DRUG UTILIZATION
ERYTHROMYCIN
AZITHROMYCIN
SLOVENIA