Author/Editor		Šuškovič, Stanislav; Košnik, Mitja; Rekič, Slobodan
Title		Delovanje in prenašanje cetirizina pri bolnikih z alergijskim rinitisom
Translated title		Effect and tolerance of cetirizine in patients with allergic rhinitis
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 70, št. 3
Publication year		2001
Volume		str. 143-7
Language		slo
Abstract		Background. H1 antihistamines are important drugs for allergic rhinitis or conjunctivitis. Antihistaminic tests have mainly been compared with placebo effects in clinical tests. Significantly less clinical comparisons among particular antihistamines have been made. Patients and methods. In the study we compared the cetirizine or loratadine effect and tolerance in patients with allergic rhinitis or allergic rhinoconjunctivitis. 66 patients were included in the study. 59 patients were convenient for statistical processing. By random selection the patients were treated by cetirizine or by loratadine. Every morning in the study period the patients received 10 mg of cetirizine (A group) or loratadine (B group). The study lasted for 14 days. We evaluated general symptoms (headache, fatigue, concentration disorders, and sleep disorders), nose symptoms (sneeze, nose itch, nose percolation, and nose occlusion), and eyes symptoms (eyes itch, lacrimation, and conjunctives injection), took notes of side effects, and monitored treatment clinically and electrocardiographically. Results. Cetirizine and loratadine significantly decreased all studied general symptoms and allergic rhinitis or allergic conjunctivitis symptoms. In the cetirizine group the symptoms explicitness was statistically significantly decreased in time, save with the lacrimation symptom. In the loratadine group the symptoms explicitness was statistically significantly decreased in time, save with headache symptoms and concentration disorders. By means of the t-test we found out that in the fatigue symptom decrease cetirizine was more efficient than loratadine. With other symptoms the difference was not statistically significant. But with no symptom the double factor variant analysis showed statistically significant difference between the groups as to the time and type of treatment. (Abstract truncated at 2000 characters).
Summary		Izhodišča. Antihistaminiki H1 so pomembna zdravila za alergijski rinitis ali konjunktivitis. V kliničnih preizkusih so večinoma primerjali učinke antihistaminika z učinki placeba. Kliničnih primerjav med posameznimi antihistaminiki je bilo narejenih bistveno manj. Bolniki in metode. V raziskavi smo primerjali učinkovanje in prenašanje cetirizina ali loratadina pri bolnikih z alergijskim rinitisom ali alergijskim rinokonjunktivitisom. V študijo je bilo vključenih 66 bolnikov. Za statistično obdelavo je bilo primernih 59 bolnikov. Bolnike smo po naključnem izboru zdravili s cetirizinom ali z loratadinom. V času raziskave so bolniki prejeli vsako jutro 10 mg cetirizina (skupina A) ali loratadina (skupina B). Raziskava je trajala 14 dni. Vrednotili smo splošne simptome (glavobol, utrujenost, motnje v koncentraciji in motnje spanja), simptome s strani nosu (kihanje, srbečica nosu, nosni izcedek in zamašenost nosu) in simptome s strani oči (srbenje oči, solzenje in injekcijo konjunktiv), beleži stranske učinke in klinično ter elektrokardiografsko spremljali zdravljenje. Rezultati. Cetirizin in loratadin sta pomembno zmanjševala vse preučevane splošne simptome in simptome alergijskega rinitisa ali alergijskega konjunktivitisa. V skupini Cetirizin se je izraženost simptomov s časom statistično pomembno zmanjševala, razen pri simptomu solzenja. V skupini Loratadin se je izraženost simptomov s časom statistično pomembno zmanjševala, razen pri simptomih glavobola in motenj v koncentraciji. Z uporabo t-testa smo ugotovili, da je bil cetirizin pri zmanjševanju simptoma utrujenosti uspešnejši kot loratadin. Pri ostalih simptomih razlika ni bila statistično značilna. Vendar pa pri nobenem simptomu dvofaktorska analiza variance glede na čas in vrsto zdravljenja ni pokazala statistično pomembnih razlik med skupinama. Pomembnih stranskih učinkov nismo ugotovili niti pri cetirizinu niti pri loratadinu. (Izvleček prekinjen pri 2000 znakih).
Descriptors		RHINITIS, ALLERGIC, PERENNIAL HAY FEVER CETIRIZINE LORATADINE CONJUNCTIVITIS, ALLERGIC TREATMENT OUTCOME HEADACHE FATIGUE