Author/Editor     Reljič, Milan; Vlaisavljević, Veljko; Gavrić, Vida; Kovačič, Borut; Čižek-Sajko, Mojca
Title     Value of the serum estradiol level on the day of human chorionic gonadotropin injection and on the day after in predicting the outcome in natural in vitro fertilization/intracytoplasmic sperm injection cycles
Type     članek
Source     Fertil Steril
Vol. and No.     Letnik 75, št. 3
Publication year     2001
Volume     str. 539-43
Language     eng
Abstract     Objective: To predict the risk of premature ovulation and possibility of pregnancy in natural IVF/ICSI cycles on the basis of the estradiof (E2) level on the day of hCG injection and on the day after. Design: A prospective study. Setting: Hospital research program. Patient(s): One hundred sixty-four women undergoing 305 IVF/ICSI natural cycles. lntervention(s): Serum E2 levels were measured - 12 h before (day 0) and 12-17 h after hCG administration (day 1). Main Outcome Measure(s): E2 levels on day 0 and day 1, the ratio of the day l to day 0 levels, and cycle outcome. Result(s): In cycles with premature ovulation and in conception cycles, the average E2 level on day 0 was statisticaliy significantly higher than in other cycles; whereas the E2 ratio was statistically significantly lower. Muitiple logistic regression was used to determine the connection of the E2 level on day 0 (B0 =-0.742; B =2.147, P =.01) and the E2 ratio (B0=-0.742, B =-3.135; P<.001) with premature ovulation. Only the E2 ratio B0 = 0.659, B = -2.209, P=.0068) was significantly connected with conception. Conclusion(s): In predicting the outcome of natural IVF/ICSI cycles, the importance in the E2 level on the day of hCG administration or on the day after, but rather in the E2 ratio.
Descriptors     FERTILIZATION IN VITRO
ESTRADIOL
OVULATION INDUCTION
GONADOTROPINS, CHORIONIC
OVUM IMPLANTATION
MENSTRUAL CYCLE
SPERMATOZOA
OOCYTES
LOGISTIC MODELS