Author/Editor		Czarnecki, Andrzej
Title		Pharmacoepidemiology - a tool to contemporary pharmacotherapy
Translated title		Farmakoepidemiologija - orodje sodobne farmakoterapije
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 49, št. Spec Issue
Publication year		1998
Volume		str. 105-8
Language		eng
Abstract		Pharmacoepidemiology (PhE) is a relatively new scientific field. Its role is to investigate a drug, specifically its safe use in the large population: The major aim is to extend the knowledge of a drug collected during clinical trials in small groups of selected patients. It is extremely important that such information is gathered therefore all members of the medical profession should to be involved in the monitoring of drug safety to detect any health hazard as quickly as possible. Recent drug safety issues of anorectic drugs and unusual heart disease, nucleozide analogs and liver damage and others provide strong proof of importance of pharmacoepidemiology in contemporary pharmacotherapy. Pharmacoepidemiology collects adverse drug reactions and usage data and evaluates risk/benefit ratio if needed arises. This data also allows to address the issues of effectiveness and socioeconomics. Without appropriate application of PhE the contemporary pharmacotherapy which is safe, effective and adequate for the population is not possible.
Summary		Farmakoepidemiologija (PHE) spada med novejše znanstvene discipline. V središču njenega zanimanja je zdravilo, v prvi vrsti njegova varna uporaba pri večjih populacijah. Glavni cilj PhE je dopolnjevanje znanja o zdravilu na osnovi podatkov, predhodno dobljenih v študijah kliničnega preizkušanja zdravil. Za te študije je znano, da potekajo v majhnih skupinah predhodno izbranih pacientov. Zelo pomembno je, da so vsi pripadniki medicinske (in farmacevtske) stroke vključeni v spremljanje varnostnih profilov zdravil s ciljem, da bi kar najhitreje odkrili potencialne nevarnosti za zdravje populacije, ki jih zdravila utegnejo povzročiti. Problemi z varnostjo nekaterih anorektičnih zdravil v povezavi z boleznimi srca, nukleozidnih analogov in z njihovo uporabo povezane poškodbe jeter itd. pomenijo dokaz pomembnosti farmakoepidemiologije v sodobni farmakoterapiji. Farmakoepidemiologija zbira podatke uporabi zdravil in o njihovih neželjenih stranskih učinkih in v primeru potrebe vrednoti razmerje med tveganjem in koristjo uporabe zdravila (risk/benefit ratio). Ti podatki dopuščajo tudi preverjanje učinkovitosti in socioekonomskih lastnosti zdravila. Brez primerne uporabe farmakaepidemiologije ni sodobne t.j. varne, učinkovite in adekvatne farmakoterapije.
Descriptors		PHARMACOEPIDEMIOLOGY