Author/Editor		Pirtošek, Zvezdan
Title		Ko zmanjkuje dopamina - počasen, otrdel bolnik, ki se trese in pada
Translated title		When dopamine is decreased - a slow, rigid and shaky patient who tends to fall
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 1
Publication year		2001
Volume		str. 3-8
Language		slo
Abstract		Descriptions of possible parkinsonism appeared in ancient medical texts from India, China, Egypt, Greece and Rome; however, the disorder has been nosologically defined by James Parkinson in 1817. It can be divided into various groups: idiopathic Parkinson's disease, parkinsonism plus, secondary parkinsonism and psychogenic parkinsonism. The pathogenetic mechanism (decreased dopamine due to cell degeneration in substantia nigra) has been clarified, however, the questions about the cause of the degeneration remain unanswered, as well as the reasons for the selective vulnerability of dopaminergic cells in substantia nigra. Possible causes include aging, genetic and environmental factors, such as infection or toxins; a combined mechanism is also plausible. Extrapolating from epidemiological studies, there may be approximately 4000 parkinsonian patients in Slovenia.
Summary		Opisi možnega parkinsonizma se javljajo v mnogih medicinskih spisih stare Indije, Kitajske, Egipta, antične Grčije in Rima, bolezen pa je prvi opredelil leta 1817 angleški zdravnik James Parkinson. Ločimo več vrst parkinsonizma: idiopatsko Parkinsonovo bolezen, parkinsonizem plus, sekundarni parkinsonizem in psihogeni parkinsonizem. Patogenetski mehanizem (pomanjkanje dopamina zaradi degeneracije celic v substanci nigri) je dobro raziskan, še vedno pa ne vemo, kaj je vzrok degeneracije in zakaj proces prizadene predvsem dopaminergične neurone substance nigre. Možni vzroki so genetski, procesi staranja, vplivi iz okolja (okužbe, toksini) ali kombinacija več dejavnikov. Glede na epidemiološke študije je v Sloveniji približno 4000 bolnikov.
Descriptors		PARKINSON DISEASE, SYMPTOMATIC DOPAMINE