Author/Editor		Flisar, Dušan
Title		Ko levodopa ne poamaga - parkinsonski sindromi
Translated title		When levodopa doesn't help - parkinsonian syndromes
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 1
Publication year		2001
Volume		str. 15-9
Language		slo
Abstract		The commonest cause of parkinsonism is Parkinson's disease. Its diagnosis remains entirely clinical. However, studies from parkinsonian brain banks have shown that one quarter of cases still carrying, at death, a diagnosis of idiopathic Parkinson's disease made by a specialist, did not have the disease. The article concentrates on the conditions most frequently mistaken for Parkinson's disease, such as multiple system atrophy, progressive supranuclear palsy, vascular parkinsonism and drug induced parkinsonism, and gives a short overview of other rare causes of parkinsonism. The paper also gives a list of clinical clues which may be useful in differentiating these atypical parkinsonian syndromes from Parkinson's disease. The most important one is absent or only transitory response to levodopa.
Summary		Parkisonova bolezen je najpogostejši vzrok parkinsonizma. Diagnoza Parkinsonove ni je še vedno klinična. Študije možganov umrlih bolnikov so pokazale, da je bila četrtina diagnoz, ki so jih še za časa življenja bolnikov postavili specialisti, napačnih. Članek natančneje obravnava stanja, ki jih najpogosteje zamenjamo za Parkinsonovo bolezen, kot so multipla sistemska atrofija, progresivna supranuklearna pareza, vaskularni parkinsonizem in parkinsonizem zaradi zdravil. Našteti so tudi opozorilni klinični znaki, ki pomagajo pri razločevanju atipičnih parkinsonizmov od Parkinsonove bolezni. Najpomembnejši med njimi je neodzivnost ali samo prehodna odzivnost na levodopo.
Descriptors		PARKINSON DISEASE, SYMPTOMATIC LEVODOPA OLIVOPONTOCEREBELLAR ATROPHY SUPRANUCLEAR PALSY, PROGRESSIVE