Author/Editor		Rudolf, Zvonimir
Title		Maligni melanom
Translated title		Malignant melanoma
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 1
Publication year		2001
Volume		str. 41-6
Language		slo
Abstract		The incidence rate of malignant melanoma of the skin is increasing throughout the world as well as in Slovenia and has, in fact, doubled in the last decade. Planning of the further treatment after radical removal of the primary tumor depends upon the histologically determined depth of the invasion (Clark's classification, tumor size). Larger tumors should be additionally treated with interferon. So far, the results of treating the disease in its advanced stage have not been satisfactory A response to chemotherapy was obtained in a maximum of 20 percent of patients. Therefore, the two most decisive prognostic factors are early detection of the lesion and radical surgical treatment, whereas in larger tumors, adjuvant treatment with interferon is an additional prognostic factor. A greater survival rate may be assured by earlier detection of primary tumors.
Summary		Maligni melanom kože narašča tako v svetu kot tudi v Sloveniji. Incidenca se podvoji v 10 letih. Vodilo za nadaljnje zdravljenje po radikalni odstranitvi primarnega tumorja je histološko določena globina invazije (Clarkovi nivoji, debelina tumorja). Pri debelejših tumorjih je priporočljivo dodatno zdravljenje z interferonom. Rezultati zdravljenja napredovale bolezni so še vedno nezadovoljivi. S kemoterapijo dosežemo odgovor le največ pri 20 % bolnikov. Najpomembnejša napovedna dejavnika sta zato zgodnja prepoznava lezije in radikalno kirurško zdravljenje; pri debelejših tumorjih pa še dodatno zdravljenje z interferonom. Za podaljšanje preživetja je pomembno zgodnejše odkrivanje primarnih tumorjev.
Descriptors		MELANOMA NEOPLASM STAGING SURVIVAL ANALYSIS NEOPLASM METASTASIS