Author/Editor		Oblak, Duša; Žnidar, Jelka
Title		Karvedilol - novejši blokator beta v zdravljenju ishemične bolezni srca
Translated title		Carvedilol - a novel beta blocker in the treatment of ischaemic heart disease
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 1
Publication year		2001
Volume		str. 73-6
Language		slo
Abstract		Carvedilol is a novel beta-blocker of the third generation with vasodilatory action. It reduces arterial blood pressure, heart rate and cardiac output by cardio-nonselective beta and alfa1 blocking activity. In addition, carvedilol exerts a favorable effect on the metabolism of blood lipids and blood glucose. Beta-blockers are the drugs of choice for the treatment of angina pectoris, as well as in patients following a myocardial infarction. Due to its double action carvedilol reduces cardiac work. It therefore relieves symptoms and improves exercise tolerance in patients with stable angina. Treatment with carvedilol reduces the recurrence rate of myocardial infarction, manages angina pectoris, improves heart failure and reduces mortality.
Summary		Karvedilol je novejši blokator beta tretje generacije z vazodilatacijskim učinkom. S kardioneselektivnim zaviranjem receptorjev beta in alfal zmanjšuje arterijslci krvni tlak, srčno frekvenco in minutni volumen srca. Ugodno deluje na presnovo krvnih maščob in krvnega sladkorja. Blokatorji beta so izbirno zdravilo za zdravljenje angine pektoris in bolnikov po prebolelem miokardnem infarktu. Zaradi dvojnega učinka razbremeni srčno mišico. Pri bolnikih s stabilno angino pektoris zdravljenje s karvedilolom zmanjša simptome in poveča telesno zmogljivost. Pri bolnikih po prebolelem miokardnem infarktu karvedilol zmanjša število ponovnih infarktov, zmanjša simptome angine pektoris, izboljša srčno popuščanje in zmanjša umrljivost.
Descriptors		CORONARY DISEASE ADRENERGIC BETA-ANTAGONISTS ANGINA PECTORIS MYOCARDIAL INFARCTION