| Author/Editor | Malešič, Ivan | |
| Title | Laboratorijska diagnostika gastrointestinalnih bolezni | |
| Translated title | Laboratory diagnostics of gastrointestinal diseases | |
| Type | članek | |
| Source | Farm Vestn | |
| Vol. and No. | Letnik 49, št. Spec Issue | |
| Publication year | 1998 | |
| Volume | str. 337-44 | |
| Language | slo | |
| Abstract | In diagnosing gastrointestinal diseases laboratory tests are of extreme importance. In gastroenterology the majority of clinical biochemical tests are enzyme tests. Higher activities of certain organic specific enzymes in sera are a very sensitive indicator of tissue lesion of these organs and they greatly surpass all possible morphological diagnostics as well as other laboratory tests. Early detection of toxic effects of drugs on intestinal organs, especially liver, is only possible by enzyme tests. Early, timely detection of malignant diseases of the gastrointestinal tract is a major problem. Some new tumour markers bring hope and we can expect possible early sera diagnostics of malignant intestinal tumours. There is an intensive search for more sensitive methods of determination of tumour antigenes. Biochemical determination of fecal occult blood is of major importance, as screening test for determination of colorectal cancer, which is the most frequent malignant tumour of the intestines. In choosing the method, resp. the test set for determining fecal occult blood, sensitivity is one of the most important parameters. Our results of sensitivity tests of some methods as well as conclusions made, regarding implementation of this important test are shown here. | |
| Summary | Laboratorijske preiskave so v diagnostiki bolezni prebavil izredno pomembne. Večina klinično biokemičnih preiskav v gastroenterologiji je encimskih preiskav. Zvišane aktivnosti določenih organsko specifičnih encimov v serumu so zelo občutljiv pokazatelj lezije tkiv teh organov, daleč pred vsemi morfološkimi diagnostičnimi možnostmi kakor tudi drugimi laboratorijskimi testi. Toksičnost zdravil na prebavne organe, predvsem jetra, lahko ugotovimo že zelo zgodaj, edino z encimskimi preiskavami. Velik problem je zgodnja, pravočasna diagnostika malignih obolenj prebavnega trakta. Nekateri novo odkriti tumorski označevalci vlivajo upanje in pričakovanje na možnosti bolj zgodnje serološke diagnostike malignih novotvorb prebavil. Intenzivno se iščejo bolj občutljive metode določanja teh tumorskih antigenov. Biokemično ugotavljanje okultne krvi v blatu je posebej pomembno, kot presejalni test, na rak debelega črevesa in danke, ki je najpogostejši maligni tumor na prebavilih. Občutljivost je eden od najpomembnejših parametrov pri izboru postopka, oziroma reagenčnega kompleta za ugotavljanje okultne krvi v blatu. Prikazani so naši rezultati testiranja na občutljivost nekaterih postopkov in sklepi, ki smo jih prejeli glede izvajanja to pomembne preiskave. | |
| Descriptors | GASTROINTESTINAL DISEASES GASTRIC JUICE PANCREATIC FUNCTION TESTS COLORECTAL NEOPLASMS OCCULT BLOOD PEPSIN A LIVER DISEASES LIVER FUNCTION TESTS PANCREATIC DISEASES |