Author/Editor		Matos, Tadeja; Beović, Bojana
Title		Odpornost na protiglivna zdravila
Translated title		Resistance to antifungals
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 2
Publication year		2001
Volume		str. 65-72
Language		slo
Abstract		In the last few decades the rate of fungal infections has increased. The use of antifungal agents became widespread and was followed by the development of resistance. The antifungal susceptibility testing remained problematic and unreliable. In the last few years a new method M-27A was developed and started to be used world-wide. In comparison with older methods the results of M-27A are reproducible and comparable. In studies, published recently, clinical correlation of laboratory breakpoints has been investigated. Susceptibility testing of fungal isolates is recommended for fungi, isolated from sterile specimens and in the eases of therapeutic failure. In spite of great progress in the field of antifungal susceptibility testing, a clinician should be aware of many other factors influencing the outcome of fungal infection besides the in vitro effective antifungal agent. In the review article the mechanisms of antifungal resistance, the method of susceptibility testing, the breakpoints and the clinical impact of the antifungal testing are discussed in details.
Summary		V zadnjih desetletjih je močno naraslo število glivnih okužb. Široki uporabi protiglivnih zdravil postopno sledi razvoj odpornosti na antimikotike. Določanje občutljivosti gliv na protiglivna zdravila je težavno in nezanesljivo. V zadnjih letih so razvili metodo, M-27A, ki se je uveljavila po svetu in zagotavlja ponovljivost in primerljivost rezultatov. Opravljene so bile tudi nekatere raziskave, ki poskušajo in vitro izmerjene vrednosti povezati s kliničnim uspehom zdravljenja. Ugotavljanje občutljivosti priporočajo pri osamitvi gliv iz sterilnih kužnin in pri kliničnem neuspehu zdravljenja. Kljub velikemu napredku na področju določanja občutljivosti gliv na antimikotike pa se moramo zavedati, da je učinkovitost protiglivnega zdravljenja le eden od dejavnikov, ki pri bolniku z glivno okužbo vplivajo na ozdravitev. V preglednem članku sa podrobno obravnavani mehanizmi odpornosti gliv, metoda določanja občutljivosti, mejne vrednosti in klinični pomen rezultatov laboratorijskih preiskav.
Descriptors		ANTIFUNGAL AGENTS DRUG RESISTANCE AZOLES IMIDAZOLES POLYENES MICROBIAL SENSITIVITY TESTS