Author/Editor		Krstulović, Ana; Krznarić, Željko; Rudolf, Maja; Ostojić, Rajko; Vucelić, Boris; Malenica, Branko
Title		Prevalence of antineutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis
Translated title		Učestalost antineutrofilnih citoplazmatskih autoantitijela (ANCA) u bolesnika s autoimunim hepatitisom
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 49, št. Spec Issue
Publication year		1998
Volume		str. 425-31
Language		eng
Abstract		The prevalence of antineutrophil cytoplasmic autoantibodies (ANCA) was evaluated in 115 serum samples from patients with various chronic liver diseases. The presence of ANCA was detected on ethanol-fixed cytospin preparations of peripheral blood neutrophils by indirect immunofluorescence. A perinuclear (pANCA) staining pattern was considered positive. The ANCA autoantibodies were detected in 17% (7/42) of patients with autoimmune hepatitis, in 6% (1/17) of patients with primary biliary cirrhosis and in 7% (2/30) of patients with secondary biliary cirrhosis. ANCA was not found in patients with chronic hepatitis (O/26). Among patients with autoimmune hepatitis, ANCA were selectively observed in 509'0 (6/12) of patients with type 1 autoimmune hepatitis. These resultsindicate that ANCA may be usefulin the differential diagnosis of different types of autoimmune hepatitis.
Descriptors		HEPATITIS ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT LIVER CIRRHOSIS, BILIARY