Author/Editor		Pokorn, Marko; Čižman, Milan; Primožič, Janez; Babnik, Janez; Kopriva, Silvo
Title		Preprečevanje okužb z respiratornim sincicijskim virusom s hiperimunimi gamaglobulini in monoklonskimi protitelesi
Translated title		The prevention of infections with respiratory syncytial virus with hyperimmune RSV gammaglobulin and specific monoclonal RSV antibodies
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 2
Publication year		2001
Volume		str. 91-5
Language		slo
Abstract		Respiratory syncytial virus is the most common cause of lower respiratory tract infections in children < 12 months of age. From 0.5 to 3.2% of children with RSV infection require hospitalization. High-risk conditions for severe RSV infection include prematurity, chronic lung disease, congenital heart defects, immune deficiencies and age < 6 weeks. Since an effective therapy for RSV infection does not exist nor there is an effective vaccine, passive immunization with anti-RSV antibodies remains the only means to prevent RSV infections. The results of clinical trials of hyperimmune RSV gammaglobulin and specific monoclonal RSV antibodies in premature children and in those <_ 24 months of age with chronic lung disease are presented. Although both hyperimmune globulin and monoclonal antibodies are effective in the prevention of RSV infection, their use is limited by high price as confirmed by several economic analyses. Experts in the USA and Europe have set guidelines for the use of hyperimmune globulin and monoclonal antibodies for prevention of RSV infection in high-risk groups.
Summary		Respiratorni sincicijski virus (RSV) je najpogostejši povzročitelj okužb spodnjih dihal pri otrocih v prvem letu življenja. Bolnišnično zdravljenje potrebuje 0,5 do 3,2 % otrok z RSV-okužbo. RSV-okužba bolj ogroža prezgodaj rojene otroke, tiste s kronično pljučno boleznijo, s prirojeno srčno hibo, z imunsko pomanjkljivostjo in mlajše od 6 tednov. Ker učinkovitega zdravila za zdravljenje okužbe z RSV nimamo, prav tako pa ne obstaja učinkovito cepivo, je zaščita s protitelesi prod RSV edini učinkovit ukrep za preprečevanje okužb z RSV Predstavljeni so rezultati kliničnih raziskav učinkovitosti hiperimunih gamaglobulinov proti RSV in specifičnih monoklonskih protiteles proti RSV pri preprečevanju okužb z RSV pri prezgodaj rojenih otrocih ter pri otrocih, starih do 24 mesecev s kronično pljučno boleznijo. Čeprav so protitelesa učinkovita pri preprečevanju okužb z RSV, pa jih pri uporabi omejuje njihova visoka cena, kar potrjujejo rezultati večine ekonomskih analiz. Zato so strokovnjaki v ZDA in Evropi pripravili priporočila za uporabo protiteles proti RSV pri otrocih, ki jih RSV-okužbe posebej ogrožajo.
Descriptors		RESPIRATORY SYNCYTIAL VIRUS INFECTIONS GAMMA-GLOBULINS ANTIBODIES, MONOCLONAL VACCINATION IMMUNIZATION, PASSIVE