Author/Editor		Pavčnik, Dušan; Uchida, BT; Timmermans, H; Corless, CL; Keller, FS; Roesch, J
Title		Aortic and venous valve for percutaneous insertion
Type		članek
Source		Minim Invasive Ther Allied Technol
Vol. and No.		Letnik 9, št. 3-4
Publication year		2000
Volume		str. 287-92
Language		eng
Abstract		The purpose of this paper is to present in vitro and in vivo experimental evaluation of a new, artificial, bicuspid, aortic and venous valve. Valves were constructed from square stents with barbs covered by porcine small intestine submucosa (SIS). A valve 15 mm in diameter was tested in a flow model (2.5 I/min) with pressure measurement. A 100-m1 rubber bag attached to a side arm of the flow model simulated heart ejection fraction. In acute (n=6) and short-term (n=3) experiments conducted in four swine and four dogs, valves ranging from 16 - 28mm in diameter were placed into the ascending aorta through 10F sheaths; three were placed subcoronary and six in a supracoronary position. Function and stability of the valves were studied with pressure measurements and aortograms. Three short-term animals were sacrificed for gross and histologic evaluation at one, two and four weeks respectively. In an acute experiment, venous valves with four barbs were placed into the IVC through an 8F guiding catheter in three dogs. For longer-term testing, valves were placed into the IVCs and iliac veins of three young swine. The animals were followed up after two weeks with venograms, then were sacrificed for gross and histologic evaluation.
Descriptors		HEART VALVE PROSTHESIS AORTIC VALVE MITRAL VALVE DOGS SWINE AORTOGRAPHY STENTS