Author/Editor		Bunc, Gorazd; Kovačič, Srečko; Strnad, Simona
Title		Sympathetic nervous system exclusion following experimental subarachnoid haemorrhage prevents vasospasm in rabbits
Type		članek
Source		Wien Klin Wochenschr
Vol. and No.		Letnik 112, št. 12
Publication year		2000
Volume		str. 533-39
Language		eng
Abstract		Background: The objective of this study was to establish whether the exclusion of the effect of the sympathetic nervous system prevents vasospasm of cerebral arteries after experimental subarachnoid haemorrhage in rabbits.Methods: The effect of sympathetic exclusion on vasospasm was studied in 29 New Zealand rabbits under conditions similar to human subarachnoid haemorrhage:1. The activity of the sympathetic nervous system was excluded only after subarachnoid haemorrhage. 2. The effect of this exclusion was evaluated on the eighth day after subarachnoid haemorrhage. 3. The single haemorrhage model of experimental subarachnoid haemorrhage was chosen. Four groups of rabbits were investigated. The control group A comprised rabbits without subarachnoid haemorrhage: group B consisted of those with subarachnoid haemorrhage (1 ml autologous blood/kg BW suboccipitally into the cisterna magna): group C included those with subarachnoid haemorrhage and pharmacological sympathetic exclusion by the alpha blocker phenoxybenzamine, and group D was composed of those with subarachnoid haemorrhage and operative sympathetic exclusion by cervical gangliectomy. Changes in the basilar arteries of rabbits were evaluated by computer image analysis, using histologic specimens of vessel walls. A new measuring procedure was developed to assess the intensity of vasospasm: the method has a corrugation coefficient that expresses changes in intimal corrugation. (Abstract truncated at 2000 characters).
Descriptors		SUBARACHNOID HEMORRHAGE CEREBRAL ARTERIES VASOCONSTRICTION PHENOXYBENZAMINE RABBITS SYMPATHETIC NERVOUS SYSTEM