Author/Editor		Meglič, Anamarija
Title		Sposobnost spreminjanja oblike eritrocitov in mikrohematurija pri otrocih in mladostnikih
Translated title		Erythrocyte deformability and microhematuria in children and adolescents
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 67
Language		slo
Abstract		Introduction. Asymptomatic isolated microhematuria in children and adolescents often remains unexplained. The mechanism of microhematuria with certain renal disorders can be explained by the passage of erythrocytes through an abnormal glomerular filtration barrier. In individuals with no laboratorial and clinical signs which would indicate to a renal disorder, the mechanism of microhematuria can only be conjectured. In my opinion it is possible that in individuals with increased erythrocyte deformability, erythrocytes pass also through a normal glomerular basement membrane more easily and in greater number. There are many disorders accompanied by reduced erythrocyte deformability. As regards increased erythrocyte deformability related to haematuria, no data were found. Aim. The aim of this study was to find out whether erythrocyte deformability is increased in otherwise healthy children and adolescents with unexplained asymptomatic isolated glomerular microhematuria and whether it is accompanied by fixed erythrocyte cell characteristics in this individuals. Subjects. Erythrocyte deformability in 33 children and adolescents with unexplained asymptomatic isolated microhematuria (study group) were compared to erythrocyte deformability in individuals distributed in three control groups, i.e. 133 children, adolescents and young adults without urinary tract disease and without microhematuria first control group), 26 patients with microhematuria and a confirmed renal disorder IgA glomerulonephropathy (second control group) and 31 children and adolescents with benign familial hematuria and suspected or histologically verified thin glomerular basement membrane (third control group). All subjects in the study had normal blood count according to their age and sex. (Abstract truncated at 2000 characters)
Descriptors		HEMATURIA ERYTHROCYTE DEFORMABILITY ERYTHROCYTE INDICES CHILD ADOLESCENCE AGE FACTORS KIDNEY GLOMERULUS BASEMENT MEMBRANE FILTRATION