Author/Editor		Velenšek-Prestor, Veronika; Rakovec, Peter; Koželj, Mirta; Jereb, Berta
Title		Late cardiac damage of anthracycline therapy for acute lymphoblastic leukemia in childhood
Type		članek
Source		Pediatr Hematol Oncol
Vol. and No.		Letnik 17, št. 7
Publication year		2000
Volume		str. 527-40
Language		eng
Abstract		Long-term leukemia survivors (46) underwent cardiac evaluation, including physical examination, ECG, exercise testing, and echocardiography. They were 2-17 years old at diagnosis and 5-23 years old after treatment. Thirty-four survivors received anthracyclines (AC:) (mean 203 mg/m2), 12 of them had also alkylating agents (AA) and 12 had no A C. Exercise tolerance was bellow predicted values in 21 (48 % ) survivors and 21 survivors had ECG abmormalities, which were more frequent in those Greated with AC. Concomitant AC with AA zuas correlated with prolonged isovolumic relaxation time (IVRT) and influenced significantly the volume of left atriurn (p = . 02). Sixteen (52 % ) survivors had IVRT > 90 ms. There were no significant differences in other parameters of diastolic or systolic function. Despite the lack of clinical symptoms in the survivors treated with lower doses of AC, subtile abnormalities in myocardial function were found, mainly manifest as abnormal diastolic function. Prolonged IVRT may be a sensitive indicator for early detection of AC cardiotoxicity.
Descriptors		LEUKEMIA, LYMPHOCYTIC, ACUTE DOXORUBICIN HEART CHILD ELECTROCARDIOGRAPHY ECHOCARDIOGRAPHY, DOPPLER ANTHRACYCLINES