Author/Editor     Damiani, S; Pasquinelli, G; Lamovec, J; Peterse, JL
Title     Acinic cell carcinoma of the breast: an immunohistochemical and ultrastructural study
Type     članek
Source     Virchows Arch
Vol. and No.     Letnik 437, št. 1
Publication year     2000
Volume     str. 74-81
Language     eng
Abstract     The clinicopathological features of six cases of breast carcinomas showing features of acinic cell differentiation, which are similar to those seen in homologous tumors of salivary glands, are presented. The patients, all women, were 35-80 years of age. One case recurred after 4 years, and in two cases axillary lymph node metastases were found at the time of surgery. Histologically the tumors showed a microglandular pattern merging with solid areas. Cytologically, immunohistochemically, and ultrastructurally the tumors were very similar to cases of acinic cell carcinoma of the parotid gland.The differential diagnostic criteria with microglandular adenosis and carcinomas showing granular cytoplasm are discussed. It seems that acinic cell carcinomas of the breast have to be added to the long list of tumors that affect the salivary glands and can also arise in the breast.
Descriptors     BREAST NEOPLASMS
CARCINOMA, ACINAR CELL
IMMUNOHISTOCHEMISTRY
MURAMIDASE
AMYLASES
ALPHA 1-ANTICHYMOTRYPSIN