Author/Editor		Prechtl, A; Harbeck, N; Thomssen, C; Meisner, C; Braun, M; Untch, M; Wieland, M; Lisboa, B; Čufer, T; Graeff, H
Title		Tumor-biological factors uPA and PAI-1 as stratification criteria of a multicenter adjuvant chemotherapy trial in node-negative breast cancer
Type		članek
Source		Int J Biol Markers
Vol. and No.		Letnik 15, št. 1
Publication year		2000
Volume		str. 73-8
Language		eng
Abstract		In axillary node-negative primary breast cancer, 70% of the patients will be cured by locoregional treatment alone. Therefore, adjuvant systemic therapy is only needed for those 30% of node-negative patients who will relapse after primary therapy and eventually die of metastases. Traditional histomorphological and clinical factors do not provide sufficient information to allow accurate risk group assessment in order to identify node-negative patients who might benefit from adjuvant systemic therapy. In the last decade various groups have reported a strong and statistically independent prognostic impact of the serine protease uPA (urokinase-type plasminogen activator) and its inhibitor PAI-1 (plasminogen activator inhibitor type 1) in node-negative breast cancer patients. Based on these data, a prospective multicenter therapy trial in node-negative breast cancer patients was started in Germany in June 1993, supported by the German Research Association (DFG). Axillary node-negative breast cancer patients with high levels of either or both proteolytic factors in the tumor tissue were randomized to adjuvant CMF chemotherapy versus observation only. Recruitment was continued until the end of 1998, by which time 684 patients had been enrolled. Since then, patients have been followed up in order to assess the value of uPA and PAI-1 determination as an adequate selection criterion for adjuvant chemotherapy in node-negative breast cancer patients. This paper reports on the rationale and design of this prospective multicenter clinical trial, which may have an impact on future policies in prognosis-oriented treatment strategies.
Descriptors		BREAST NEOPLASMS LYMPHATIC METASTASIS PLASMINOGEN ACTIVATOR INHIBITOR 1 UROKINASE CLINICAL TRIALS CHEMOTHERAPY, ADJUVANT PROGNOSIS PROSPECTIVE STUDIES