Author/Editor		Mavri, Alenka; Gužič-Salobir, Barbara; Salobir-Pajnič, Barbara; Keber, Irena; Stare, Janez; Stegnar, Mojca
Title		Seasonal variation of some metabolic and haemostatic risk factors in subjects with and without coronary artery disease
Type		članek
Source		Blood Coagul Fibrinolysis
Vol. and No.		Letnik 12, št. 5
Publication year		2001
Volume		str. 359-65
Language		eng
Abstract		Acute myocardial infarction (AMI) is more frequent in winter than in summer months. The etiologic mechanisms underlying this seasonal pattern are poorly understood. We investigated whether seasonal variation of metabolic and haemostatic coronary risk factors exists and if this variation is more pronounced in subjects with coronary artery disease (CAD). In 82 subjects (47 free of clinical signs of CAD and in 35 survivors of AMl), measurements of body mass index (BMI), lipoproteins, glucose, insulin, plasminogen activator inhibitor-1 (PAI-1), tissue type plasminogen activator (t-PA), euglobulin clot lysis time (ECLT), fibrinogen, and platelet count were performed twice in the cold (December and March) and twice in the warm (June and September) months. Significantly higher BMI (26.8 vs 25.2 kg/m2, p<0.01), glucose (5.5 vs 5.1 mmol/L, p<O.OI), total cholesterol (5.61 vs 5.32 mmol/L, p<0.05), LDL cholesterol (3.63 vs 3.34 mmol/L, p<0.05), triglycerides (1.79 vs l.61 mmol/L, p<0.01), Lp(a) (270.7 vs 237.5 mg/L, p<0.01), fibrinogen level (3.50 vs 2.95 g /L, p <0.00001), platelet count (212 vs 173x10 9/L, p<0.01) and significantly lower HDL cholesterol level (1.22 vs 1.28 mmol/L, p<0.05) were observed in the cold compared to the warm months. Significant seasonal variation of t-PA activity (1.19 vs 0.87 IU/mL, p=0.015) and t-PA antigen (8.5 vs 7.3 ng/mL, p=0.05) was demonstrated only in subjects with CAD. Clustering of peak values of several metabolic and haemostatic coronary risk factors was observed in winter months. This variation might be of etiopathogenetic importance for the seasonal pattern of acute myocardial infarction.
Descriptors		MYOCARDIAL INFARCTION HEMATOLOGIC TESTS SEASONS RISK FACTORS CORONARY DISEASE BODY MASS INDEX LIPOPROTEINS BLOOD GLUCOSE INSULIN PLASMINOGEN ACTIVATOR INHIBITOR 1 ALTEPLASE FIBRINOGEN CLOT RETRACTION PLATELET COUNT ANALYSIS OF VARIANCE