Author/Editor		Jelenc, Marjetka
Title		Vpliv nekaterih dejavnikov na hipertrofijo levega prekata pri arterijski hipertenziji brez nočnega znižanja krvnega tlaka
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 92
Language		slo
Abstract		Left ventricular hypertrophy is a risk factor for cardiovascular morbidity and mortality in patients with essential hypertension. Insulin resistance and increased sympathetic nervous system activity are also suggested to be risk factors for cardiovascular morbidity. The purpose of the present study was to evaluate the relationship of hyperinsulinemia, insulin resistance, glucose metabolism and sympathetic nervous system activity to left ventricular mass in patients with essential hypertension in whom blood pressure does not fall during sleep (non-dippers) compared to essential hypertensives with blood pressure fall during sleep (dippers). We would like to find out if they are some differences in glucose and insulin metabolism between the two groups of hypertensives and if hiperinsulinemia or cathecholamines are related to development of left ventricular hypertrophy in the group of non-dippers. Thirthyfour male, non-diabetic out-patients with essential arterial hypertension were included in the study: 23 dippers (mean age 44 +- 11 years; body mass index 27 +- 3 kg/m2) and 11 non-dippers (mean age 48 +- 11 years, body mass index 27 +- 3 kg/m2). Patients were subdivided in dippers and non-dippers on the basis of 24-hour ambulatory blood pressure monitoring. We measured body weight, height and calculated body mass index. A bidimensional echocardiographic analysis was performed on every enrolled subject. For assessment of left ventricular mass, measurements of posterior wall thickness, interventricular septal thickness and left ventricular internal dimensions were made. Left ventricular mass was calculated according to the formula of Devereux. Left ventricular mass was normalized for body surface and body height. An oral glucose load of 75 g was administered, and blood samples for plasma glucose and insulin measurements were taken before, and 30, 60, and 120 min after the glucose load. (Abstract truncated at 2000 characters).
Descriptors		HYPERTENSION HYPERTROPHY, LEFT VENTRICULAR BODY HEIGHT BODY WEIGHT BODY MASS INDEX NUTRITION SURVEYS BLOOD PRESSURE DETERMINATION INSULIN RESISTANCE HEART RATE HYPERINSULINEMIA CATECHOLAMINES INSULIN C-PEPTIDE EPINEPHRINE NOREPINEPHRINE LIPIDS