Author/Editor		Strojan, Primož
Title		Prognostic value of cathepsin and their endogenous inhibitors in squamous cell carcinoma of the head and neck
Translated title		Napovedni pomen katepsinov in njihovih endogenih inhibitorjev pri ploščatoceličnem karcinomu glave in vratu
Type		članek
Source		Acta Biol Slov
Vol. and No.		Letnik 43, št. 1-2
Publication year		2000
Volume		str. 31-6
Language		eng
Abstract		The prognostic value of tumour and serum concentrations of cathepsins D, B, H, and L, stefins A and B, and cystatin C were evaluated in squamous carcinoma of the head. The risk of disease recurrence was significantly higher (P<0.05) in patients with low tumour concentrations of stefins A, B or cystatin C. For cathepsins, the survival results were either not conclusive (cathepsins H, L) or not significant (cathepsins B, D). Of the serum concentrations, only that of cathepsin L appeared to be of prognostic value.
Summary		V raziskavi smo poskušali ovrednotiti napovedno vrednost katepsinov D, B, H in L, stefinov A in B ter cistatina C pri ploščatoceličnem karcinomu glave in vratu. Statistično značilno večjo verjetnost ponovitve bolezni smo zabeležili pri bolnikih z nizko tumorsko koncentracijo stefina A, stefina B ali cistatina C; v primeru katepsinov so bili rezultati analize preživetja bodisi nekonkluzivni (katepsina H in L) ali statistično neznačilni (katepsina B in D). Izmed serumskih koncentracij se je kot prognostično pomembna izkazala le koncentracija katepsina L.
Descriptors		HEAD AND NECK NEOPLASMS CARCINOMA, SQUAMOUS CELL CATHEPSINS CYSTEINE PROTEINASE INHIBITORS CATHEPSIN D CATHEPSIN B CYSTATINS PROGNOSIS RECURRENCE