Author/Editor		Meglič, Bernard; Graus, Francesc; Grad, Anton
Title		Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma
Type		članek
Source		J Neurol Sci
Vol. and No.		Letnik 185
Publication year		2001
Volume		str. 135-8
Language		eng
Abstract		Paraneoplastic cerebellar degeneration (PCD) with anti-Yo antibodies is almost always associated with ovarian and breast cancer. We describe a man with anti-Yo-positive PCD and gastric adenocarcinoma. The tumor cells were labeled with anti-Yo antibodies by immunohistochemistry. High serum titers of anti-Yo antibodies were found before surgery and decreased 6 months after resection of the tumor. The expression of Yo antigens by the tumor and the decrease in anti-Yo antibody titers after its removal suggest that the immune response against the Purkinje cells of the cerebellum was triggered by the tumor.
Descriptors		PARANEOPLASTIC SYNDROMES CEREBELLAR NEOPLASMS STOMACH NEOPLASMS ADENOCARCINOMA AGED IMMUNOHISTOCHEMISTRY