Author/Editor		Jenicke, Lars; Klutmann, Susanne; Bohuslavizki, Karl H; Neuber, Karsten; Altenhoff, Juergen; Wedler, Juliane; Buchert, Ralph; Nebeling, Bruno; Clausen, Malte
Title		Conventional staging and 18F-FDG-PET staging of malignant melanoma
Translated title		Določanje razširjenosti bolezni pri bolnikih z melanomom na konvenzionalni način ali z 18F-FDG-PET
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 35, št. 2
Publication year		2001
Volume		str. 95-103
Language		eng
Abstract		Background. Preliminary reports suggest that PET using 18F-FDG may be a valuable diagnostic tool in patients with advanced malignant melanoma. Therefore, the aim of this study was to compare the findings of 18F-FDG-PET and those of conventional imaging including physical examination for both primary and follow-up staging of patients with malignant melanoma. Patients and methods. Thirthy-five patients with histologically proven malignant melanoma underwent 61 PET examinations. After an intravenous injection of 370 MBq 18F-FDG, whole-body images were acquired on an ECAT EXACT 47 (921) with an axial field-view of 16.2 cm. Moreover, all patients underwent physical examination and conventional imaging, i.e. ultrasound, CT, and MRI within a two-week interval after 18F-FDG-PET. Based on the findings of both staging procedures, the patients were classified according to UICC. Results. In primary staging or follow-up, 5 out of 35 patients were classified as stage I by conventional staging. Seven out of 35 patients were classified as stage II. The remaining 23 patients were initially classified as stage III. In the follow-up, two out of the latter 23 patients were upstaged to stage IV. However, none of these patients was classified as stage IV in primary staging by conventional diagnostic procedures. According to the results of 18F-FDG-PET, 9 out of 35 patients revealed neither evidence for distant metastases nor presence of lymph node metastases in primary staging (stage I/II). However, initially 21 out of 35 patients were suspected for lymph node metastases but no distant metastases (stage III). (Abstarct truncated at 2000 characters).
Summary		Izhodišča. Doslej opravljene predhodne raziskav potrjujejo, da je 18F-FDG-PET (pozitronska emisija tomografija z 18-deoksifluorglukozo) zelo koristna preiskava za določanje razširjenosti napredovanega malignega melanoma. Namen naše raziskave je bil primerjati rezultate slikanja s 18F-FDG-PET ter rezultate konvencionalnega slikanja in kliničnega pregleda bolnikov z malignim melanomom tako pri primarnem ugotavljanju razširjenosti bolezni kot pri ugotavljanju njene razširjenosti na kontrolnih pregledih. Bolniki in metode. Skupini 35 bolnikov s histološko potrjenim malignim melanomom smo opravili 61 PET preiskav. Ko smo jim vbrizgali 370 MBq +F-FDG, smo poslikali celotno telo z napravo ECAT EXACT 47 (921) z aksialnim vidnim poljem 16,2 cm. Vseh 35 bolnikov smo v štirinajstih dneh po slikanju s 18F-FDG-PET tudi klinično pregledali in opravili konvencionalne preiskave, kot so ultrazvočna preiskava, CT in MRI. Na osnovi rezultatov obeh metod za določanje razširjenosti bolezni smo bolnike razvrstili v skupine v skladu s klasifikacijo UICC. Rezultati. Pri primarnem določanju razširjenosti bolezni in pri ugotavljanju njene razširjenosti na kontrolnih pregledih s konvencionalnimi metodami smo pri 5 od 35 bolnikov ugotovili, da je bolezen v stadiju I in pri 7 od 35 bolnikov da je v stadiju II. Pri ostalih 23 bolnikih smo sprva določili melanom v stadiju III. Na kontrolnih pregledih smo pri 2 od 23 bolnikov ugotovili višji stadij melanoma, in sicer stadij IV. Vsekakor pri primarnem določanju razširjenosti bolezni s konvencionalnimi diagnostičnimi slikovnimi metodami pri nobenem od bolnikov nismo ugotovili stadija IV. Pri primarnem določanju razširjenosti bolezni s preiskavo 18F-FDG-PET pri 9 od 35 bolnikov nismo odkrili niti zasevkov v bezgavkah niti oddaljenih zasevkov (stadij I/II). Pri 21 od 35 bolnikov je obstajal sum na razširjenost zasevkov v bezgavkah, ni pa bilo suma oddaljenih zasevkov (stadij III). (Izvleček prekinjen pri 2000 znakih).
Descriptors		MELANOMA NEOPLASM STAGING TOMOGRAPHY, EMISSION-COMPUTED CONTRAST MEDIA