Author/Editor		Poredoš, Pavel
Title		Etiopatogeneza ateroskleroze
Translated title		Pathogenesis of atherosclerosis
Type		članek
Source		In: Hojs R, Krajnc I, Pahor A, editors. Zbornik predavanj in praktikum 12. srečanje internistov in zdravnikov splošne medicine Iz prakse za prakso z mednarodno udeležbo; 2001 maj 11-12; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2001
Volume		str. 43-58
Language		slo
Abstract		The development of the atherosclerotic process is reviewed together with the typical morphological changes in the vessel wall, and the mechanisms triggering atherosclerosis. Among several hypotheses on the development of atherosclerosis the most plausible one remains the over 100-year old hypothesis of endothelial injury as the initiating event, which is followed by lipid deposition and deposition of ohter plasma components in the arterial wall. The advanced atherosclerotic process involves in addition to the intima also the deeper arterial wall layers. An advanced atherosclerotic plaque is often complicated by thrombosis on the uneven surface of the plaque. In recent years the prevailing opinion that atherosclerosis is primarily a degenerative process has been challenged by the view that it is in fact an inflammatory process in the arterial wall. The inflammation is either a response to injury or to infection by bacteria or viruses. The fibrinolytic system has an important role in thromboembolic complications of atherosclerosis, but it may also be one of the etiopathogenetic factors in atherosclerosis.
Descriptors		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR MACROPHAGES CHOLESTEROL OXIDATIVE STRESS INFLAMMATION INFECTION FIBRINOLYSIS