Author/Editor		Skok, Pavel
Title		Jetrna ciroza in zapleti
Translated title		Liver cirrhosis and complications
Type		članek
Source		In: Hojs R, Krajnc I, Pahor A, editors. Zbornik predavanj in praktikum 12. srečanje internistov in zdravnikov splošne medicine Iz prakse za prakso z mednarodno udeležbo; 2001 maj 11-12; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2001
Volume		str. 179-92
Language		slo
Abstract		Cirrhosis is a chronic liver disease, best defined morphologically as a process characterized by fibrosis and the conversion of normal liver architecture into structurally abnormal nodules. The process is diffuse and involves the whole organ. Hepatocellular necrosis, which is regarded as an important initial lesion in cirrhosis, may no longer be apparent at the time of diagnosis and is not included in most definitions. The most frequent causes of of this disease worldwide are alcohol and viral hepatitis, types B and C. Aetiological diagnosis is usually reached by a combination of epidemiological, clinical, biochemical, immunological and histological features. Clinically cirrhosis may develop without giving rise ao any symptoms. As the lesion progresses, it has two major consequences, hepatic failure and portal hypertension. This conditions are responsible for the main complications of cirrhosis, jaundice, ascites, encephalopathy, and digestive hemorrhage. Cirrhosis without any of this complications may be designated as compensated cirrhosis. Cirrhosis with one or several of these complications is usually referred to as decompensated cirrhosis. The prognosis of liver cirrhosis depends on its etiology, epidemiological setting, clinical and laboratory manifestations, severity of histological lesions and possibilities of treatment. Liver transplantation has significantly improved the outcome of this patients.
Descriptors		LIVER CIRRHOSIS ASCITES JAUNDICE HEPATIC ENCEPHALOPATHY GASTROINTESTINAL HEMORRHAGE FEVER