Author/Editor		Lovšin, Boštjan
Title		Etiologija prezgodnjega poroda
Translated title		Etiology of preterm labour and delivery
Type		članek
Source		In: Novak-Antolič Ž, editor. Prezgodnji porod in nedonošenček. Zbornik prispevkov 8. Novakovi dnevi z mednarodno udeležbo; 2001 maj 31-jun 2; Maribor. Ljubljana: Slovensko zdravniško društvo, Združenje za perinatalno medicino,
Publication year		2001
Volume		str. 56-63
Language		slo
Abstract		Preterm deliveries are a leading cause of neonatal morbidity and mortality in the world. Efforts to prevent preterm deliveries have been hampered by a poor understanding of the underlying pathophysiology and the mechanisms involved. There is an increasing clinical and laboratory evidence that many preterm deliveries result from premature activation of cells in the cervix, decidua and fetal membranes in response to local mediators of maternal or fetal stres, ascending genital infection, and/or decidual hemorrhage. Putative mediators include corticotropin releasing hormone (CRH) and inflammatory cytokines which promote the production of oxytocic factors capable of eliciting uterine contractions. The majority of the leading causes of preterm deliveries could be explained through these evidenced and putative mediators: ascending genital infection, anomalous placentation, fetal malformations, uterine anomalies, multiple pregnancies and endocrine causes. An improved understanding of mechanisms involved in preterm deliveries can provide new approaches to the early detection of patients at high risk, prevention and management of preterm deliveries.
Descriptors		LABOR, PREMATURE PREGNANCY COMPLICATIONS PREGNANCY