Author/Editor		Valič, B; Pavlin, M; Miklavčič, D
Title		Model of induced transmembrane potential on spheroidal cell
Type		članek
Source		Medicon 2001. 9th Mediterranean conference on medical and biological engineering and computing. 2nd Croatian-Slovenian meeting on biomedical engineering. 1st international conference on muscle fibre structure and function. 5th symposium of Croatian society for medical informatics (Medicine informatics 2001). Proccedings of the International federation for medical and biological engineering. Part 1, Part 2; 2001 Jun 12-15; Pula
Publication year		2001
Volume		str. 837-40
Language		eng
Abstract		Induced transmembrane potential is critical parameter for successful cell permeabilization. In our study we analysed the effect of cell shape and orientation on induced transmembrane potential due to applied electric field. Biological cells can be represented with spheroids having different ratios -delta between smaller and larger radius. We used finite-elements method to calculate induced transmembrxne potential on spheroidal cell fur different cell orientation and shape. We validated our model by comparing our results with analytical solutions for parallel orientation. Our results show that for more spheroidal cells (larger p) maximum induced transmembrane potential changes significantly, as well as area of the cell, which is exposed to voltage above threshold. This could explain experimental results on cell suspensions where it was shown that longer pulses improve electropermeabilization due to orientation of cells parallel to the field.
Descriptors		ELECTROPORATION MEMBRANE POTENTIALS CELL SIZE MODELS, THEORETICAL