Author/Editor		Veingerl, Bojan
Title		Značenje razine karcinoembrijskog antigena u serumu bolesnika operiranih zbog kolorektalnog karcinoma kao mjerilo uspješnosti liječenja i prognoze
Type		monografija
Place		Zagreb
Publisher		Sveučilište u Zagrebu, Medicinski fakultet
Publication year		2000
Volume		str. 69
Language		cro
Abstract		Background. The only method of treatment offering a favorable prognosis for colorectal carcinoma is radical resection of part of the colon or rectum including the pertaining lymph glands and eventual radical removal of metastases. But even such assumably curative surgery does not warrant full recovery of all operated patients as recurrences are frequent and according to most analyses 5-year survival is under 50%. The most significant reason for this for this poor therapeutic success lies in residual micrometastases not detected in the course of surgery and which may also be located extraregionally i.e. in peripheral blood or bone marrow. Therefore additional treatment is attempted in some patients. Various prognostic factors of disease recurrence are helpful. One such prognostic sign is serum carcinoembryonic antigen (CEA) level measured soon after surgery. Material and methods. All patients opeated electively for colorectal carcinoma at our institution within one year were followed. According to their preoperative serum CEA levels they were divided into the control group (preoperative CEA under 10 ng/mL) and the working group (preoperative CEA over 10 ng/mL). From the working group patients with radical R0 resection were then chosen, and according to their postoperative serum CEA levels and the CEA half-life they were devided into three groups: CEA R0, CEA R1 and CEA R2 resected patients. All patients were then followed for 24 months, the number of recurrences and the survival rate were observed. Results. A statistically significant difference regarding survival and number of recurrences was noted among patients divided according to the stage of disease, particularly between our three groups of patients from the working group undergoing assumably curative surgery. After two years survival in the CEA R0 group was 96.97% in the CEA R1 group 66.66% and in the CEA R2 group 50%. (Abstract truncated at 2000 characters).
Descriptors		COLORECTAL NEOPLASMS CARCINOEMBRYONIC ANTIGEN TREATMENT OUTCOME PROGNOSIS NEOPLASM STAGING