Author/Editor		Dettbarn, Wolf D; Milatović, Dejan; Živin, Marko; Gupta, Ramech C
Title		Oxidative stress, acetylcholine and excitotoxicity
Type		članek
Source		In: Marwah J, Kanthasamy A, editors. Antioxidants and free radicals in health and disease. Scottsdale: Prominent press,
Publication year		2001
Volume		str. 184-206
Language		eng
Abstract		This chapter gives an overview based on experiments investigating the hypothesis that a causal relationship exists between the generation of reactive oxygen species (ROS), lipid peroxidation and excitotoxicity. Reactive oxygen species are suggested to contribute to muscle fiber and neuronal damage associated with cholinergic excitotoxicity. Most of the evidence is based on indirect techniques such as determination od products of lipid peroxidation. The results of expeiments using direct determination of reactive oxygen species with spin trapping agents are difficult to interpret due to lack of identification and quantification of the reactive oxygen species involved. Spin trapping agents have numerous pharmacological actions unrelated to trapping of ROS, and these should be considered when explaining the protection afforded by spin trapping agents.
Descriptors		OXIDATIVE STRESS ACETYLCHOLINE REACTIVE OXYGEN SPECIES LIPID PEROXIDATION NERVOUS SYSTEM RATS MUSCLE FIBERS NEURONS SPIN TRAPPING NEUROMUSCULAR JUNCTION ACETYLCHOLINESTERASE CHOLINESTERASE INHIBITORS MALONDIALDEHYDE XANTHINE OXIDASE CYTOCHROME-C OXIDASE GLUTATHIONE FREE RADICAL SCAVENGERS SEIZURES