Author/Editor		Trontelj, Jože V
Title		Single fibre electromyography: guidelines for jitter measurement by axonal stimulation
Type		članek
Source		In: International SFEMG course and 7th quantitative EMG conference; 2001 Jun 10-15; Uppsala. Uppsala: ,
Publication year		2001
Volume		str. 1-20
Language		eng
Abstract		This text describes the techniques for performing jitter study by axonal microstimulation, one of the most common applications of Single Fibre Electromyography (SFEMG). Only the essential guidelines are given. For details, see Stalberg & Trontelj 1994 or Trontelj and Stalberg 1992. Stimulation SFEMG has evolved into a useful modification of the original method introduced in the 60s by Ekstedt and Stalberg. It is based on a combination of well controllable, highly selective activation with highly selective recording. Among the advantages of the method is its greater precision, since only single neuromuscular junctions rather than pairs are studied, and the often disturbing effect of muscle fiber velocity recovery function can be eliminated. The main use of stimulation SFEMG is in the diagnosis of neuromuscular transmission disorders, in which it offers high sensitivity (over 95%) Moreover, the study of individual neuromuscular junctions at different stimulation rates may help in differentiation between the pre- andpostsynaptic abnormalities. The method is suitable to detect muscle fiber splitting, a common finding in certain neuromuscular disorders. Direct intrafascicular muscle fiber stimulation allows precise measurement of propagation velocity (a function of muscle fiber diameter) and its recovery function (abnormal in muscular dystrophies). The phenomenon of action potential recovery function may provide a useful and sensitive parameter in evaluating depolarisation-repolarisation abnormalities, such as in genetically determined or drug-induced myotonic disorders. Myogenic block of conduction can be detected in sarcolemmal ion channel abnormalities. Stimulation SFEMG allows reliable identification of the various late responses to nerve stimulation, e.g., differentiation between the recurrent (F) and H-reflex responses. (Abstract truncated at 2000 characters).
Descriptors		ELECTROMYOGRAPHY NERVE FIBERS AXONS NEUROMUSCULAR DISEASES NEUROMUSCULAR JUNCTION PRACTICE GUIDELINES