Author/Editor		Poredoš, P
Title		Endothelial dysfunction - what does this mean and how to measure it?
Type		članek
Source		In: Clement D, Rieger H, editors. Proceedings of the 14th congress of the European chapter of the International union of angiology; 2001 May 23-26; Cologne, Germany. Bologna: Monduzzi editore,
Publication year		2001
Volume		str. 243-52
Language		eng
Abstract		Helathy endothelium plays a central role in cardiovascular control. Therefore endothelial dysfunction (ED), which is characterized by an inbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between proinflammatory and antiinflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Endothelial dysfunction is closely related to different risk factors of atherosclerosis, to their intensity and their duration. The involvement of risk factors in ED is also supported by results of interventions studies that showed regression of ED with treatment of risk factors. The common denominator whereby different risk factors cause ED is most probably increased oxidative stress. Endothelial dysfunction promote atherosclerosis and probably plays an important role in the development of thrombotic complications in late stages of the disease. As ED is a key underlying factor in the atherosclerotic process, markers of endothelial abnormalities have been sought. Detection of ED is based on tests of endothelium-dependent vasomotion (dilation capability of peripheral and coronary arteries) and on circulating markers of endothelial function (endothelin-1, von Willebrand factor, TPA, PAI, adhesion molecules). Using these tests it is possible to follow the dose - response of harmful effects or risk factors, and the effects of preventive procedures on vessel wall function.
Descriptors		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR OXIDATIVE STRESS RISK FACTORS ENDOTHELIN-1 VON WILLEBRAND FACTOR ALTEPLASE PLASMINOGEN ACTIVATOR INHIBITOR 1 VASCULAR CELL ADHESION MOLECULE-1 E-SELECTIN INTERCELLULAR ADHESION MOLECULE-1