Author/Editor		Puhan, Simona; Ostaševski, Nina
Title		Napovedna vrednost celičnih in humoralnih imunskih parametrov pri otrocih
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2000
Volume		str. 50
Language		slo
Abstract		The study covers 809 children treated in the Alergic Department of the Paediatric Clinic and examined regarding the parameter values of lymphocyte populations from venous blood. Inside the examination group separate groups were defined: a control group, a group of children with allergy, and a group of children with hypogammaglobulinemia. The study was finding out a connection between concentrations of lymphocyte populations in the childrens venous blood and the clinical state of the examined children. In the first part of the study, average values were defined in each group for a specific lymphocyte parameter, but the values of specific parameters of lymphocyte populations were compared among separate groups to the Students test t. In the group of children with proven allergy or atopy, there are comparing to the control group characteristically (p < 0.05) increased concentrations of the lymphocytes T, the cells CD4, and the ratio of CD4/CD8. In the group of children with proven hypogammaglobulinemia, there are comparing to the control group characteristically increased (p < 0.05) concentrations of the lymphocytes T, the cells T CD4 and the shares of lymphocytes, lymphocytes T, cells T CD4, cells T CD8, activated (HLA-DR) lymphocytes T and cells NK. Furthermore the ratio CD4/CD8 is also characteristically increased. In the second part of the study, two upper limits were set for separate lymphocyte parameters. A share of children was established the immune parameters of whom surpassed the chosen cut-off value for separate parameters of lymphocyte populations. By means of the test HI2, the parameters of lymphocyte populations were shown with regard to which the expected frequency of children was above the cut-off value with allergy or hypogammaglobulinemia characteristically different from the expected frequency of the children above the cut-off value with the population of the children without allergy or hypogammaglobulinemia. (Abstract truncated at 2000 characters).
Descriptors		HYPERSENSITIVITY AGAMMAGLOBULINEMIA T-LYMPHOCYTES CHILD CD4 LYMPHOCYTE COUNT CD4-CD8 RATIO HLA-DR ANTIGENS FLOW CYTOMETRY IGG IGA IGM ENZYME-LINKED IMMUNOSORBENT ASSAY SKIN TESTS