Author/Editor		Potočnik, Igor; Tomšič, Martin; Bajrović, Fajko
Title		Sensitivity of sensory axons to lidocaine nerve block in rats
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 442, št. 6 Suppl 1
Publication year		2001
Volume		str. R193-4
Language		eng
Abstract		The aim of the present study was to test the sensitivity of different classes of sensory axons to lidocaine 2 and 4% nerve block. The basic approach was to examine changes in compound action potential (CAP) of A and C axons of the rat sural nerve induced by 2 or 4% lidocaine nerve block in vitro. CAP in control sural nerves (n = 6 for each experimental group) -before nerve block was induced, consisted of the early component (A axons: 0.3 +- 0.02 ms) and the late component (C axons: 12.2 +- 1.14 ms) with peak voltage amplitudes 4.4 +- 1.4 mV and 0.04 +- 0.02 mV, respectively. Lidocaine 2% nerve block completely abolished the amplitude of CAP of C axons and depressed the amplitude of CAP of A axons to about 20 % of control level. Doubled concentration of lidocaine significantly decreased time taken to develop maximal depression of CAP and significantly increased excitation threshold of sensory A axons; but not of sensory C axons. However, 4% lidocaine did not affect the maximal depression of CAP of sensory A axons. These results support the view, that C axons are more sensitive to lidocaine nerve block than A axons. In addition, our results suggest a population of sensory A axons which is non-sensitive to 2% and 4 % lidocaine.
Descriptors		NERVE BLOCK LIDOCAINE SURAL NERVE ACTION POTENTIALS RATS, WISTAR AXONS