Author/Editor		Kokelj, F; Plozzer, C
Title		Severe oral involvement in a case of Hand-Schuller-Christian disease
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 10, št. 3
Publication year		2001
Volume		str. 107-9
Language		eng
Abstract		We report the case of a patient with diabetes insipidus who came to our observation because of severe lesions of the oral mucosa. He referred that he had lost all his molars and three incisors over the past two years. The clinical cutaneous examination revealed the presence of small yellowish-brown papules on the forehead only. A biopsy performed from the gingival mucosa showed the presence of Langherans cells and a dense inflammatory infiltrate. The immunohistochemical examination showed CD1 antigenic determinant and S-100 protein positive. Considering the presence of diabetes insipidus, the clinical, histological, immunohistochemical picture, the diagnosis was of a Hand-Shuller-Christian disease. The patient underwent chemotherapy and radiotherapy. Three months after the end of the therapy a gingival biopsy confirmed the success of the treatment.
Descriptors		HAND-SCHUELLER-CHRISTIAN SYNDROME DIABETES INSIPIDUS ORAL MANIFESTATIONS IMMUNOHISTOCHEMISTRY LANGERHANS CELLS TREATMENT OUTCOME