Author/Editor | Kovačič, Borut; Vlaisavljević, Veljko | |
Title | Oploditev in nepravilnosti oploditve po vnosu semenčice v jajčno celico pri človeku | |
Translated title | Fertilization and fertilization anomalies in humans after sperm injection into the oocyte | |
Type | članek | |
Source | Med Razgl | |
Vol. and No. | Letnik 40, št. 1 | |
Publication year | 2001 | |
Volume | str. 95-105 | |
Language | slo | |
Abstract | Fertilization is the process of paternal and maternal chromosomes uniting in the activated oocyte. The most frequent reason for fertilization failure is sperm incapacity to penetrate into the oocyte. In such cases the gametes can be united mechanically, but the fusion of their chromosomes is resigned to the action of the ooplasm. The condition required for uniting is synchroneous decondensation of paternal and maternal chromatin and formation of a male and female pronucleus. Chromatin transformation is not always coordinated, which may lead to fertilization arrest. With the technique of immunofluorescent microscopy of oocytes failing to fertilize, allowing the simultaneous observation of chromatin and pertaining microtubules - the most important structures for chromosome dynamics during fertilization, we can establish anomalies in the process of gamete union and elucidate some of their causes. | |
Summary | Oploditev je proces združevanja očetovskih in maternih kromosomov v aktivirani jajčni celici. Najpogpstejši vzrok za neoplojenostje nesposobnost semenčic, da bi prodrle v jajčno celico. V takšnih primerih lahko spolne celice pojimo tudi mehansko, združevanje njihovih kromosomov pa prepustimo delovanju ooplazme. Pogoj za združitev kromosomov je skladno razvitje očetovskega in maternega kromatina in nastanek moškega in ženskega pronukleusa. Preoblikovanje kromatina ni vedno usklajeno, kar lahko privede do zastoja oploditve. Tehnika imunofluorescenčne mikroskopije neuspešno oplojenih jajčnih celic nam omogoča sočasno opazovanje kromatina in pripadajočih mikrotubulov, najpomembnejših struktur za dinamiko kromosomov med oploditvijo. Z njo lahko ugotavljamo nepravilnosti v procesu združevanja spolnih celic in nekatere vzroke zanje. | |
Descriptors | FERTILIZATION SPERM-OVUM INTERACTIONS FERTILIZATION IN VITRO SPERMATOZOA |